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Top Cast
Oprah Winfrey
Deborah Lacks
Rose Byrne
Rebecca Skloot
Renée Elise Goldsberry
Henrietta Lacks
Reg E. Cathey
Zakariyyah
Courtney B. Vance
Sir Lord Keenan Coefield
Rocky Carroll
Sonny Lacks
Leslie Uggams
Sadie
Reed Birney
Dr. George Gey
John Douglas Thompson
Lawrence Lacks
Adriane Lenox
Barbara Lacks
Roger Robinson
Day Lacks
John Beasley
Cliff
Peter Gerety
Paul Lurz
Gabriel Ebert
Christoph Lengauer
John Benjamin Hickey
Bill Watson
Ruben Santiago-Hudson
Dr. Roland Pattillo
Byron Jennings
Dr. Victor McKusick
Sylvia Grace Crim
Mary Kubicek
Karen Wheeling Reynolds
Mrs. Gey
John C. Vennema
Board Administrator
Jaedon Godley
Davon Lacks
Kyanna Simone Simpson
Deborah (15-24YRS)
Jane Rumbaua
Dr. Susan Hsu
Jaylon Gordon
Alfred
Leon Lamar
Cootie
Andrea Frye
Gladys
Jazzy Ellis
Young Gladys
Tinashe Kajese
Sadie
Patrick Walker
Cousin Fred
L. Warren Young
Day Lacks
Ellen Barkin
Sasha Walz
Michael Gaston
Richard Wilson
Kate Bond
Young Woman
Tyvonna Jones
Elsie Lacks
Bill Martin Williams
Crownsville Administrator
Mary Shaw
Woman at Pump
Tian Richards
Lawrence (16 yrs.)
Kermit Burns III
Young Cootie
Lisa Arrindell
Aunt Ethel
Jordan Eli Arellano
Young Sonny Lacks
Kayla Anderson
Johns Hopkins Student
De'Marco Arrington
Young Joe
Matthew Bernard
Johns Hopkins Student
Raphael Dante' Carr Jr.
Young Sonny
Ninja N. Devoe
Country Girl Mae
Clint Edwards
Scientist
Christopher Robert Escobar
Chris the Intern
Sean Freeland
Charlie
Elizabeth Hackler
Rebecca's Co-worker
Linden Harris
Galen (as Linden Ronel Harris)
Todd Lee
Doctor
Miguel Angel Marrero
Scientist
Sage Mayer
Young Boy
Jock McKissic
Carl the Mechanic
Tatom Pender
Johns Hopkins Nurse
Earl Poitier
Cousin Josh
David Shae
Reporter
Tashaun Stanfill-Perry
Henrietta Lacks Neighbor
Alpha Trivette
First Administrator
Terrence V. Walker
Church Patron