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Top Cast
Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Elena Franklin
Shane Detorre
Bill Murray
Frank Detorre
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Kid Rock
Kidney Rock (voice)
Molly Shannon
Mrs. Boyd
Chris Elliott
Bob
Jonathan Adams
Officer Tom (voice)
Carlos Alazraqui
Spanish Germ (voice)
Keith Anthony
Additional Character Voices (voice)
Eddie Barth
Conductor (voice)
Sally Brooks
Additional Character Voices (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Michael Carven
Additional Character Voices (voice)
Paul Christie
Dan Matter / Germ (voice)
Janis Dardaris
Additional Character Voices (voice)
Wendy Dillon
Additional Character Voices (voice)
Antonio Fargas
Chill the Flu Shot (voice)
Eddie Frierson
Frank Police Department Officer (voice)
Donald Fullilove
Doughnut (voice)
Jackie Gonneau
Additional Character Voices (voice)
Shannon Gregory
Additional Character Voices (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Rif Hutton
Charlie (voice)
Art Kimbro
Additional Character Voices (voice)
Joyce Kurtz
Additional Character Voices (voice)
Anne Lockhart
Female Red Blood Cell (voice)
Sherry Lynn
Trudy (voice)
Danny Mann
Musician Cell (voice)
Mickie McGowan
Brain Librarian (voice)
Kenny Olson
Kidney Rock Band (voice)
Jason Krause
Kidney Rock Band (voice)
Joe C.
Kidney Rock Band (voice)
Stefanie Eulinberg
Kidney Rock Band (voice)
Jimmie Bones
Kidney Rock Band (voice)
Uncle Kracker
Kidney Rock Band (voice)
Joel Silver
Police Chief (voice) (uncredited)
David Ossman
Scabies (voice) (uncredited)
John Melendez
Artie (voice)
Héctor Mercado
Additional Character Voices (voice)
Paul Pape
Male Red Blood Cell #2 (voice)
Marilyn Pasekoff
Additional Character Voices (voice)
Chris Phillips
Firefighter Doug (voice)
Lynne Redding
Additional Character Voices (voice)
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
Herschel Sparber
Bruiser (voice)
Doug Stone
Police Officer Jamie (voice)
Steve Susskind
Mob Boss Germ (voice)
Keri Tombazian
Additional Character Voices (voice)
Paul Tuerpe
Additional Character Voices (voice)
Robert Wisdom
Big Germ (voice)
Danny Murphy
Zookeeper Superintendent
Jack McCullough
Zookeeper
Will Dunn
Oyster Boy
Jackie Flynn
School Janitor
Kelsey Jordan
Bus Girl #1
Abe Farrelly
Bus Girl #2
Jesse Peter
Laughing Boy
John-Eliot Jordan
Pea Soup Manager
Nancy Byers
Pea Soup Supervisor
Kevin J. Flynn
Docky's Clamshack Waiter
Sean Gildea
Dreamy Photographer
Kathryn Frick
Nurse #1
Nikki Tyler-Flynn
Nurse #2
Elizabeth Jordan
Nurse #3
Zen Gesner
ER Doctor #1
Marc Hyman
ER Doctor #2
Zak Penn
ER Doctor #3
Diane Conrad
Zoo Visitor or Staff
Judith Conrad
Zoo Visitor or Staff
Thomas Jordan
The Zoo Visitor or Staff
Sydney J. Bartholomew Jr.
Zoo Visitor or Staff
Erica Johnson
Zoo Visitor or Staff
Bo Cleary
Pea Soup Staff
Bruce McIntyre
Pea Soup Staff
Colleen O'Donnell
Docky's Clamshack
Docky
The Bikini Gang
Joe Murphy
The Bikini Gang
Brian Mone
Police Officer
Sean Fitzgerald
Police Officer
Grace Costa
ER Nurse
Emily O’Donnell
School Girl